HCID 13673632, compound → HCID 66881270, compound

HRID 1893519Notes

Reaction equation

HRID 1893519 reaction equation
[CH2:1]=[N:2][N:3]1[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.[ClH:10].O1CCOCC1>C(OCC)C>[ClH:10].[CH3:1][NH:2][N:3]1[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 13673632HCID 13673632, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 66881270HCID 66881270, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A pale-yellow oil obtained using the compound (1.20 g, 9.5 mmol) obtained in step A and according to the method of Reference Example 37, step C was dissolved in diethyl ether (15 ml), 4N hydrochloric acid-dioxane solution (1.8 ml) was added with stirring under ice-cooling, and the solution was concentrated under reduced pressure to give the title compound (0.85 g, yield 53%) as a pale-yellow oil.

Workup

  1. customA pale-yellow oil obtained
  2. temperaturecooling
  3. concentrationthe solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-9667eb0d54384e42a42c3b3d6418c1bf
Source dataset
uspto-grants-2013_08
Patent number
US08513235B2

Reaction notes

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