反应详情

温度

120 °C

The compound (0.70 g, 2.95 mmol) obtained in step A and polyphosphoric acid (8.0 g) were mixed, and the mixture was stirred with heating at 120° C. After cooling to room temperature, the reaction mixture was poured into ice water, and diluted with ethyl acetate. The mixture was washed with water and saturated aqueous sodium hydrogen carbonate, and dried over anhydrous magnesium sulfate. The insoluble material was filtered off, and the solution was concentrated under reduced pressure to give the title compound (0.91 g) as a colorless solid.

1. temperatureAfter cooling to room temperature
2. washThe mixture was washed with water and saturated aqueous sodium hydrogen carbonate
3. dry with materialdried over anhydrous magnesium sulfate
4. filtrationThe insoluble material was filtered off
5. concentrationthe solution was concentrated under reduced pressure