Hydrogen chloride-ethyl acetate → HCID 66881276, compound

HRID 1893552Notes

Reaction equation

HRID 1893552 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH:11]C(=O)OC(C)(C)C)[C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1.[ClH:19].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:19].[Br:1][C:2]1[CH:3]=[C:4]([NH2:11])[C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86650783HCID 86650783, compound

Product 1

HCID 66881276HCID 66881276, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The compound (6.27 g, 20.0 mmol) obtained in step A was dissolved in ethyl acetate, 4N hydrochloric acid-ethyl acetate solution (25 ml, 100 mmol) was added at room temperature with stirring, and the mixture was stirred at the same temperature overnight. The precipitated solid was filtered, washed with ethyl acetate, and dried under reduced pressure to give the title compound (4.65 g, yield 93%) as a colorless solid.

Workup

  1. stirringthe mixture was stirred at the same temperature overnight
  2. filtrationThe precipitated solid was filtered
  3. washwashed with ethyl acetate
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-bd3bedd2808c48d599b9de5c7b2ec225
Source dataset
uspto-grants-2013_08
Patent number
US08513235B2

Reaction notes

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