Diethyl Ether → HCID 66938706, compound

HRID 1893583Notes

Reaction equation

HRID 1893583 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([N:10]([CH3:38])[C:11](=[O:37])[CH2:12][N:13]([C:24]2[CH:29]=[C:28]([C:30]3[N:34]=[C:33]([CH3:35])[O:32][N:31]=3)[CH:27]=[CH:26][C:25]=2[CH3:36])[CH2:14][C:15]([NH:17][CH2:18][CH2:19][NH:20][CH:21]([CH3:23])[CH3:22])=[O:16])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[ClH:39].C(OCC)(=O)C.C(OCC)C>C(OCC)(=O)C>[ClH:39].[C:1]([N:4]1[CH2:5][CH2:6][CH:7]([N:10]([CH3:38])[C:11](=[O:37])[CH2:12][N:13]([C:24]2[CH:29]=[C:28]([C:30]3[N:34]=[C:33]([CH3:35])[O:32][N:31]=3)[CH:27]=[CH:26][C:25]=2[CH3:36])[CH2:14][C:15]([NH:17][CH2:18][CH2:19][NH:20][CH:21]([CH3:23])[CH3:22])=[O:16])[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 21866389Hydrogen chloride-ethyl acetateHCID 66938707HCID 66938707, compound

Product 1

HCID 66938706HCID 66938706, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The compound (161 mg, 0.303 mmol) obtained in step E was dissolved in ethyl acetate (2 ml), 4N hydrochloric acid-ethyl acetate solution (0.16 ml) was added at room temperature with stirring, and the mixture was stirred at the same temperature for 2.5 hr. To the reaction mixture was added diethyl ether (2 ml), the precipitated solid was collected by filtration, washed with diethyl ether, and dried under reduced pressure to give the title compound (164 mg, yield 96%) as a colorless solid.

Workup

  1. stirringthe mixture was stirred at the same temperature for 2.5 hr
  2. filtrationthe precipitated solid was collected by filtration
  3. washwashed with diethyl ether
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-170c720219fe401fa6e67e9ce6707603
Source dataset
uspto-grants-2013_08
Patent number
US08513235B2

Reaction notes

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