1,1-Dimethoxyethyl(dimethyl)amine → HCID 66938462, compound

HRID 1893590Notes

Reaction equation

HRID 1893590 reaction equation
[C:1]([O:5][C:6](=[O:33])[CH2:7][N:8]([C:23]1[CH:28]=[C:27]([C:29]([NH2:31])=[O:30])[CH:26]=[CH:25][C:24]=1[CH3:32])[CH2:9][C:10]([N:12]([N:14]1[CH2:22][C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:15]1)[CH3:13])=[O:11])([CH3:4])([CH3:3])[CH3:2].CO[C:36](OC)([N:38](C)C)[CH3:37]>>[C:1]([O:5][C:6](=[O:33])[CH2:7][N:8]([CH2:9][C:10]([N:12]([N:14]1[CH2:15][C:16]2[C:21](=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:22]1)[CH3:13])=[O:11])[C:23]1[CH:28]=[C:27]([C:29]2[O:30][N:38]=[C:36]([CH3:37])[N:31]=2)[CH:26]=[CH:25][C:24]=1[CH3:32])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 878351,1-Dimethoxyethyl(dimethyl)amineHCID 66882053HCID 66882053, compound

Product 1

HCID 66938462HCID 66938462, compoundYield 75%

Procedure

Using the compound (500 mg, 1.11 mmol) of Example 81, step B, and N,N-dimethylacetamide dimethylacetal (2.5 ml), and according to the method of Example 83, step A, the title compound (406 mg, yield 75%) was obtained as a pale-bistered amorphous solid.

Sources & evidence

ORD record
ord-80fca6a4930a4fe3a9dcf05a1d1c1aeb
Source dataset
uspto-grants-2013_08
Patent number
US08513235B2

Reaction notes

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