Iodoethane → HCID 66881340, compound

HRID 1893596Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:31])[CH2:5][N:6]([CH2:17][C:18]([N:20]([N:22]1[CH2:30][C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23]1)[CH3:21])=[O:19])[C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][C:15]=1[CH3:16])[NH:12][N:11]=[CH:10]2)[CH3:2].[CH2:32](I)[CH3:33]>>[CH2:1]([O:3][C:4](=[O:31])[CH2:5][N:6]([CH2:17][C:18]([N:20]([N:22]1[CH2:23][C:24]2[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:30]1)[CH3:21])=[O:19])[C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][C:15]=1[CH3:16])[N:12]([CH2:32][CH3:33])[N:11]=[CH:10]2)[CH3:2]

Participants

Reactant 2

HCID 6340Iodoethane

HCID 66881861HCID 66881861, compound

Product 1

HCID 66881340HCID 66881340, compoundYield 69%

Procedure

Using the compound (746 mg, 1.77 mmol) of Example 241, step B and ethyl iodide (0.26 n2, 3.23 mmol), and according to the method of Example 241, step C, the title compound (549 mg, yield 69%) was obtained as a colorless amorphous solid.

Sources & evidence

ORD record: ord-f3ba733cd1f24f819147532500949d37
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08513235B2

Reaction notes

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