2,2-Difluoroethyl trifluoromethanesulfonate → HCID 66882345, compound

HRID 1893598Notes

Reaction equation

HRID 1893598 reaction equation
[CH2:1]([O:3][C:4](=[O:31])[CH2:5][N:6]([CH2:17][C:18]([N:20]([N:22]1[CH2:30][C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23]1)[CH3:21])=[O:19])[C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][C:15]=1[CH3:16])[NH:12][N:11]=[CH:10]2)[CH3:2].FC(F)(F)S(O[CH2:38][CH:39]([F:41])[F:40])(=O)=O>>[CH2:1]([O:3][C:4](=[O:31])[CH2:5][N:6]([C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][C:15]=1[CH3:16])[N:12]([CH2:38][CH:39]([F:41])[F:40])[N:11]=[CH:10]2)[CH2:17][C:18]([N:20]([N:22]1[CH2:23][C:24]2[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:30]1)[CH3:21])=[O:19])[CH3:2]

Participants

3

Reactant 2

HCID 27740892,2-Difluoroethyl trifluoromethanesulfonateHCID 66881861HCID 66881861, compound

Product 1

HCID 66882345HCID 66882345, compoundYield 70.3%

Procedure

Using the compound (767 mg, 1.82 mmol) of Example 241, step B and 2,2-difluoroethyl trifluoromethanesulfonate (534 mg, 2.49 mmol), and according to the method of Example 241, step C, the title compound (621 mg, yield 70%) was obtained as a colorless amorphous solid.

Sources & evidence

ORD record
ord-3beabebf65114ee4942bbe9f24ad02b5
Source dataset
uspto-grants-2013_08
Patent number
US08513235B2

Reaction notes

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