2,2-Difluoroethyl trifluoromethanesulfonate → HCID 66881261, compound

HRID 1893603Notes

Reaction equation

HRID 1893603 reaction equation
[CH2:1]([O:3][C:4](=[O:31])[CH2:5][N:6]([CH2:17][C:18]([N:20]([N:22]1[CH2:30][C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23]1)[CH3:21])=[O:19])[C:7]1[CH:15]=[C:14]2[C:10]([CH:11]=[N:12][NH:13]2)=[CH:9][C:8]=1[CH3:16])[CH3:2].FC(F)(F)S(O[CH2:38][CH:39]([F:41])[F:40])(=O)=O>>[CH2:1]([O:3][C:4](=[O:31])[CH2:5][N:6]([C:7]1[CH:15]=[C:14]2[C:10]([CH:11]=[N:12][N:13]2[CH2:38][CH:39]([F:41])[F:40])=[CH:9][C:8]=1[CH3:16])[CH2:17][C:18]([N:20]([N:22]1[CH2:23][C:24]2[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:30]1)[CH3:21])=[O:19])[CH3:2]

Participants

3

Reactant 2

HCID 27740892,2-Difluoroethyl trifluoromethanesulfonateHCID 66896863HCID 66896863, compound

Product 1

HCID 66881261HCID 66881261, compoundYield 68.1%

Procedure

Using the compound (1.25 g, 2.97 mmol) of Example 257, step B and 2,2-difluoroethyl trifluoromethanesulfonate (859 mg, 4.01 mmol), and according to the method of Example 241, step C, the title compound (982 mg, yield 68%) was obtained as a colorless amorphous solid.

Sources & evidence

ORD record
ord-824d0bb3ec1d464d9749eaabd43af04c
Source dataset
uspto-grants-2013_08
Patent number
US08513235B2

Reaction notes

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