Ethylamine → HCID 57930765, compound

HRID 1893916Notes

Reaction equation

HRID 1893916 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][N:6]1[C:11]2[N:12]=[C:13](S(C)(=O)=O)[N:14]=[C:15]([CH3:16])[C:10]=2[CH:9]=[CH:8][C:7]1=[O:21].[CH2:22]([NH2:24])[CH3:23]>C1COCC1>[CH2:22]([NH:24][C:13]1[N:14]=[C:15]([CH3:16])[C:10]2[CH:9]=[CH:8][C:7](=[O:21])[N:6]([CH2:5][CH2:4][CH2:3][O:2][CH3:1])[C:11]=2[N:12]=1)[CH3:23]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 57606981HCID 57606981, compound

Product 1

HCID 57930765HCID 57930765, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

8-(3-methoxypropyl)-4-methyl-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one, and a solution of 2M ethylamine in THF (20 mL) was stirred for 2 h. THF was removed under reduced pressure and the crude product was purified by flash column chromatography to give 2-(ethylamino)-8-(3-methoxypropyl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one (0.18 g, 50% yield over 2 steps).

Workup

  1. customTHF was removed under reduced pressure
  2. customthe crude product was purified by flash column chromatography

Sources & evidence

ORD record
ord-b40ac4d32b2a473ea81f36507fb3f822
Source dataset
uspto-grants-2013_08
Patent number
US08513266B2

Reaction notes

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