3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline → HCID 59277819, compound

HRID 1894180Notes

Reaction equation

HRID 1894180 reaction equation
[CH3:1][C:2]1([CH3:16])[C:6]([CH3:8])([CH3:7])[O:5][B:4]([C:9]2[CH:10]=[C:11]([NH2:15])[CH:12]=[CH:13][CH:14]=2)[O:3]1.Br[C:18]1[N:19]([CH3:23])[CH:20]=[CH:21][N:22]=1>>[CH3:23][N:19]1[CH:20]=[CH:21][N:22]=[C:18]1[NH:15][C:11]1[CH:12]=[CH:13][CH:14]=[C:9]([B:4]2[O:3][C:2]([CH3:16])([CH3:1])[C:6]([CH3:7])([CH3:8])[O:5]2)[CH:10]=1

Participants

3

Reactant 2

HCID 27346553-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)anilineHCID 27732622-Bromo-1-methyl-1H-imidazole

Product 1

HCID 59277819HCID 59277819, compound

Procedure

A solution of 3-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenylamine (0.5 g, 2.28 mmol) in 2-Bromo-1-methyl-1H-imidazole (0.367 g, 2.28 mmol) was heated in a CEM discover microwave synthesizer (50 W) at 125° C. until the reaction was complete. The reaction mixture was cooled and used directly in the next procedure. MS: [M+H]+ 300

Workup

  1. customat 125° C.
  2. temperatureThe reaction mixture was cooled

Sources & evidence

ORD record
ord-084efd0076104a4aa353ffb5a78ae366
Source dataset
uspto-grants-2013_08
Patent number
US08513276B2

Reaction notes

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