Benzyl acetone → 4-[2-(4-Phenylbutan-2-ylidene)hydrazinyl]pyridin-2(1H)-one

HRID 1894277Notes

Reaction equation

HRID 1894277 reaction equation
[NH:1]([C:3]1[CH:8]=[CH:7][NH:6][C:5](=[O:9])[CH:4]=1)[NH2:2].[CH2:10]([CH2:17][C:18](=O)[CH3:19])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[CH3:19][C:18](=[N:2][NH:1][C:3]1[CH:8]=[CH:7][NH:6][C:5](=[O:9])[CH:4]=1)[CH2:17][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 17355Benzyl acetoneHCID 136108294-Hydrazinylpyridin-2(1H)-one

Product 1

HCID 714120494-[2-(4-Phenylbutan-2-ylidene)hydrazinyl]pyridin-2(1H)-one

Procedure

In accordance with the same procedures as in Step 2 of Preparation 1, except for using 4-hydrazino-1H-pyridin-2-one (5.39 g, 43.1 mmol) prepared in Step 1 of Preparation 1 and benzylacetone (9.70 ml, 64.6 mmol), the titled compound was obtained as a white solid. (Yield: 66.5%) The product was used in the subsequent reaction without further purification.

Workup

  1. customIn accordance with the same procedures as in Step 2 of Preparation 1

Sources & evidence

ORD record
ord-1b438df3be1b489e8f7355d249524fbe
Source dataset
uspto-grants-2013_08
Patent number
US08513277B2

Reaction notes

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