Dimethylamine → HCID 12901707, compound

HRID 1894326Notes

Reaction equation

HRID 1894326 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7]([O:16][CH2:17][CH3:18])=[N:8][C:9](S(C)(=O)=O)=[N:10][CH:11]=1)=[O:5])[CH3:2].[CH3:19][NH:20][CH3:21]>C(#N)C>[CH2:1]([O:3][C:4]([C:6]1[C:7]([O:16][CH2:17][CH3:18])=[N:8][C:9]([N:20]([CH3:21])[CH3:19])=[N:10][CH:11]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 67205242HCID 67205242, compound

Product 1

HCID 12901707HCID 12901707, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
80 °C

Procedure

4-Ethoxy-2-methanesulfonyl-pyrimidine-5-carboxylic acid ethyl ester (60 mg, 0.22 mmol) was dissolved in acetonitrile. Dimethylamine (0.6 mL, 2.0 M in methanol) was added and reaction mixture was stirred in seal tube at 80° C. for 3 h. The reaction progress was checked by LC-MS. After the reaction was completed, it was concentrated to give 2-dimethylamino-4-ethoxy-pyrimidine-5-carboxylic acid ethyl ester as a white solid (50 mg). LR-MS: 239 [(M+H)+]

Workup

  1. customreaction mixture
  2. concentrationit was concentrated

Sources & evidence

ORD record
ord-49b83bb4b2684b6a8e9ef4efd72a00f2
Source dataset
uspto-grants-2013_08
Patent number
US08513239B2

Reaction notes

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