Dimethylamine → HCID 12901707, compound

Participants

Reaction Conditions

Reaction Steps

4-Ethoxy-2-methanesulfonyl-pyrimidine-5-carboxylic acid ethyl ester (60 mg, 0.22 mmol) was dissolved in acetonitrile. Dimethylamine (0.6 mL, 2.0 M in methanol) was added and reaction mixture was stirred in seal tube at 80° C. for 3 h. The reaction progress was checked by LC-MS. After the reaction was completed, it was concentrated to give 2-dimethylamino-4-ethoxy-pyrimidine-5-carboxylic acid ethyl ester as a white solid (50 mg). LR-MS: 239 [(M+H)+]

Provenance & Evidence