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Hydrochloric Acid → 4-(Methanesulfonylmethyl)piperidine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Tert-butyl 4-((methylsulfonyl)methyl)piperidine-1-carboxylate | HCID 21087275 | — |
| 生成物 | 4-(Methanesulfonylmethyl)piperidine hydrochloride | HCID 46737055 | — |
反応手順
4-Methanesulfonylmethyl-piperidine-1-carboxylic acid tert-butyl ester as white solid (6 g) was suspended in hydrochloric acid (4N solution in 1,4-dioxane) at 0° C. The ice bath was removed and the mixture was stirred at room temperature overnight. It was concentrated to give 4-methanesulfonylmethyl-piperidine hydrochloride as white solid (4.52 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08513239B2 |
| 出典データセット | uspto-grants-2013_08 |
| ORD ID | ord-6ce130868a6848abad48a830afdcb77e |
| 出典メモ | uspto-grants-2013_08 |