Hydrochloric Acid → 4-(Methanesulfonylmethyl)piperidine hydrochloride

HRID 1894362Notes

Reaction equation

HRID 1894362 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][S:15]([CH3:18])(=[O:17])=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:19]>>[ClH:19].[CH3:18][S:15]([CH2:14][CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)(=[O:17])=[O:16]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 21087275Tert-butyl 4-((methylsulfonyl)methyl)piperidine-1-carboxylate

Product 1

HCID 467370554-(Methanesulfonylmethyl)piperidine hydrochloride

Procedure

4-Methanesulfonylmethyl-piperidine-1-carboxylic acid tert-butyl ester as white solid (6 g) was suspended in hydrochloric acid (4N solution in 1,4-dioxane) at 0° C. The ice bath was removed and the mixture was stirred at room temperature overnight. It was concentrated to give 4-methanesulfonylmethyl-piperidine hydrochloride as white solid (4.52 g).

Workup

  1. customThe ice bath was removed
  2. concentrationIt was concentrated

Sources & evidence

ORD record
ord-6ce130868a6848abad48a830afdcb77e
Source dataset
uspto-grants-2013_08
Patent number
US08513239B2

Reaction notes

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