HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-Piperazin-1-yl-propane-1-sulfonic acid amide dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-(3-sulfamoylpropyl)piperazine-1-carboxylate | HCID 67205279 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-Piperazin-1-yl-propane-1-sulfonic acid amide dihydrochloride | HCID 67204508 | — |
Reaction Steps
4-(3-Sulfamoyl-propyl)-piperazine-1-carboxylic acid tert-butyl ester (310 mg) in methanol (5 mL) was deprotected with 4 N hydrochloric acid in dioxane (3 mL) to give 3-piperazin-1-yl-propane-1-sulfonic acid amide dihydrochloride (229 mg, white solids)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08513239B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-4b10de1311984c67be0e7a73f10d2211 |
| Source note | uspto-grants-2013_08 |