Hydrochloric Acid → 3-Piperazin-1-yl-propane-1-sulfonic acid amide dihydrochloride

HRID 1894369Notes

Reaction equation

HRID 1894369 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][S:17](=[O:20])(=[O:19])[NH2:18])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:21]>CO.O1CCOCC1>[ClH:21].[ClH:21].[N:11]1([CH2:14][CH2:15][CH2:16][S:17]([NH2:18])(=[O:19])=[O:20])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67205279Tert-butyl 4-(3-sulfamoylpropyl)piperazine-1-carboxylate

Product 1

HCID 672045083-Piperazin-1-yl-propane-1-sulfonic acid amide dihydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

4-(3-Sulfamoyl-propyl)-piperazine-1-carboxylic acid tert-butyl ester (310 mg) in methanol (5 mL) was deprotected with 4 N hydrochloric acid in dioxane (3 mL) to give 3-piperazin-1-yl-propane-1-sulfonic acid amide dihydrochloride (229 mg, white solids)

Sources & evidence

ORD record
ord-4b10de1311984c67be0e7a73f10d2211
Source dataset
uspto-grants-2013_08
Patent number
US08513239B2

Reaction notes

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