反应详情

温度

0 °C

In a round bottom flask was charged with 4-pyridinepropanol (5 g, 36.45mmol), triethylamine (5.7 mL, 72.9 mmol), methylene chloride (80 mL). The solution was cooled down to 0° C. and mesyl chloride (5.7 mL, 72.9 mmol) in methylene chloride (20 mL) was slowly added. The ice bath was removed, and the mixture was stirred at room temperature overnight before being concentrated. The residue was diluted with ethyl acetate, and the organic was washed with water (2×) and brine (1×). It was dried over anhydrous sodium sulfate and concentrated to give methanesulfonic acid 3-pyridin-4-yl-propyl ester as a dark oil (6.52 g).

1. customThe ice bath was removed
2. concentrationbefore being concentrated
3. additionThe residue was diluted with ethyl acetate
4. washthe organic was washed with water (2×) and brine (1×)
5. dry with materialIt was dried over anhydrous sodium sulfate
6. concentrationconcentrated