反应详情

In a round bottom of flask was charged with 4-(3-methanesulfonyl-propyl)-pyridine (373 mg) and ethanol (5 mL). Hydrochloric acid was added (1 mL, 4N solution in dioxane) with stirring. The mixture was concentrated then the residue was taken in methanol and water. Platinum oxide (21 mg, 0.09 mmol, Aldrich) was added, and the mixture was hydrogenated at 60 psi overnight using a Parr apparatus. Upon completion, the mixture was filtered through Celite and washed thoroughly with methanol. The filtrate was concentrated to give 4-(3-methanesulfonyl-propyl)-piperidine dihydrochloride as a white solid (480.7 mg, 85% pure). The crude product was used without further purification.

1. concentrationThe mixture was concentrated
2. customwas hydrogenated at 60 psi overnight
3. filtrationUpon completion, the mixture was filtered through Celite
4. washwashed thoroughly with methanol
5. concentrationThe filtrate was concentrated