Trifluoroacetic acid → HCID 25261826, compound

HRID 1894392Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][C:11]2([CH2:18][CH2:17][N:16]([C:19]([N:21]3[C@@:25]([C:27]4[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][CH:28]=4)([CH3:26])[C@@:24]([C:35]4[CH:40]=[CH:39][C:38]([Cl:41])=[CH:37][CH:36]=4)([CH3:34])[N:23]=[C:22]3[C:42]3[CH:43]=[N:44][C:45]([C:51]([CH3:54])([CH3:53])[CH3:52])=[CH:46][C:47]=3[O:48][CH2:49][CH3:50])=[O:20])[CH2:15][CH2:14]2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>>[C:51]([C:45]1[N:44]=[CH:43][C:42]([C:22]2[N:21]([C:19]([N:16]3[CH2:15][CH2:14][C:11]4([CH2:12][CH2:13][NH:8][CH2:9][CH2:10]4)[CH2:18][CH2:17]3)=[O:20])[C@@:25]([C:27]3[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][CH:28]=3)([CH3:26])[C@@:24]([C:35]3[CH:36]=[CH:37][C:38]([Cl:41])=[CH:39][CH:40]=3)([CH3:34])[N:23]=2)=[C:47]([O:48][CH2:49][CH3:50])[CH:46]=1)([CH3:52])([CH3:53])[CH3:54]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 25261825HCID 25261825, compound

Product 1

HCID 25261826HCID 25261826, compound

Procedure

9-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-3,9-diaza-spiro[5.5]undecane-3-carboxylic acid tert-butyl ester (example 74) was treated with trifluoroacetic acid to give the title compound. HR-MS (ES, m/z) calculated for C38H48Cl2N5O2 [(M+H)+] 676.318, observed 676.3177.

Sources & evidence

ORD record: ord-e7a578dc64954c7f9337c5dd43503d09
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08513239B2

Reaction notes

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