HCID 57669984, compound → HCID 25262133, compound

HRID 1894401Notes

Reaction equation

HRID 1894401 reaction equation
[C:1]([C:5]1[N:10]=[C:9]([O:11][CH2:12][CH3:13])[C:8]([C:14]2[N:15]([C:35](Cl)=[O:36])[C@@:16]([C:28]3[CH:33]=[CH:32][C:31]([Cl:34])=[CH:30][CH:29]=3)([CH3:27])[C@@:17]([C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=3)([CH3:19])[N:18]=2)=[CH:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].Cl.Cl.[CH3:40][S:41]([CH2:44][CH2:45][CH2:46][CH:47]1[CH2:52][CH2:51][NH:50][CH2:49][CH2:48]1)(=[O:43])=[O:42]>>[C:1]([C:5]1[N:10]=[C:9]([O:11][CH2:12][CH3:13])[C:8]([C:14]2[N:15]([C:35]([N:50]3[CH2:51][CH2:52][CH:47]([CH2:46][CH2:45][CH2:44][S:41]([CH3:40])(=[O:43])=[O:42])[CH2:48][CH2:49]3)=[O:36])[C@@:16]([C:28]3[CH:33]=[CH:32][C:31]([Cl:34])=[CH:30][CH:29]=3)([CH3:27])[C@@:17]([C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=3)([CH3:19])[N:18]=2)=[CH:7][N:6]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 57669984HCID 57669984, compoundHCID 67207426HCID 67207426, compound

Product 1

HCID 25262133HCID 25262133, compound

Procedure

In a manner analogous to the method described in example 3, (4S,5R)-2-(2-tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride was reacted with 4-(3-methanesulfonyl-propyl)-piperidine dihydrochloride (example 72) to give the title compound as a racemic mixture. HR-MS (ES, m/z) calculated for C37H48Cl2N5O4S [(M+H)+] 728.2799, observed 728.2797.

Sources & evidence

ORD record
ord-9e05943a1cdc4f62871b20a854e1b337
Source dataset
uspto-grants-2013_08
Patent number
US08513239B2

Reaction notes

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