1-(3-(Methylsulfonyl)propyl)piperazine → HCID 25262284, compound

HRID 1894402Notes

Reaction equation

HRID 1894402 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH3:34])[C:12]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=3)([CH3:13])[N:11]([C:21](Cl)=[O:22])[C:10]([C:24]3[CH:29]=[C:28]([O:30][CH3:31])[N:27]=[N:26][C:25]=3[O:32][CH3:33])=[N:9]2)=[CH:4][CH:3]=1.[CH3:35][S:36]([CH2:39][CH2:40][CH2:41][N:42]1[CH2:47][CH2:46][NH:45][CH2:44][CH2:43]1)(=[O:38])=[O:37]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C@@:8]2([CH3:34])[C@:12]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=3)([CH3:13])[N:11]([C:21]([N:45]3[CH2:46][CH2:47][N:42]([CH2:41][CH2:40][CH2:39][S:36]([CH3:35])(=[O:37])=[O:38])[CH2:43][CH2:44]3)=[O:22])[C:10]([C:24]3[CH:29]=[C:28]([O:30][CH3:31])[N:27]=[N:26][C:25]=3[O:32][CH3:33])=[N:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 498534781-(3-(Methylsulfonyl)propyl)piperazineHCID 131730819HCID 131730819, compound

Product 1

HCID 25262284HCID 25262284, compound

Procedure

In a manner analogous to the method described in examples 3, rac-(4S*,5R*)-4,5-bis-(4-chloro-phenyl)-2-(3,6-dimethoxy-pyridazin-4-yl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride was coupled with 4-[3-(methylsulfonyl)propyl]-piperazine (prepared as described in Fotouhi, N. et al. WO 2005110996) to give the title compound. HR-MS (ES, m/z) calculated for C32H39Cl2N6O5S [(M+H)+] 689.2074, observed 689.2079.

Sources & evidence

ORD record
ord-176000bc959642afaeb8b2177e7d14b2
Source dataset
uspto-grants-2013_08
Patent number
US08513239B2

Reaction notes

Loading…