Hydrochloric Acid → HCID 67205887, compound

HRID 1894435Notes

Reaction equation

HRID 1894435 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:19][CH2:18][NH:17][C:16](=[O:20])[CH2:15]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:21]>CO>[ClH:21].[O:20]=[C:16]1[NH:17][CH2:18][CH2:19][N:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH2:15]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18971567HCID 18971567, compound

Product 1

HCID 67205887HCID 67205887, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

4-(3-Oxo-piperazin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (660 mg) was dissolved in methanol (5 mL) and 1 N hydrochloric acid (10 mL) was added. The mixture was stirred at 50° C. for 2 h. After removal of all solvents, acetonitrile (2×10 mL) was added and removed twice. The residue was then lyophilized to give 4-(3-oxo-piperazin-1-yl)-piperidine hydrochloride (665.8 mg).

Workup

  1. customAfter removal of all solvents, acetonitrile (2×10 mL)
  2. additionwas added
  3. customremoved twice

Sources & evidence

ORD record
ord-38a7fb8ddba1494fa23678200b5af7a7
Source dataset
uspto-grants-2013_08
Patent number
US08513239B2

Reaction notes

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