Oxamic Acid → HCID 57670128, compound

HRID 1894449Notes

Reaction equation

[NH2:1][CH:2]1[CH2:6][CH2:5][N:4]([C:7]([N:9]2[C@@:13]([C:15]3[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=3)([CH3:14])[C@@:12]([C:23]3[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=3)([CH3:22])[N:11]=[C:10]2[C:30]2[CH:31]=[N:32][C:33]([C:39]([CH3:42])([CH3:41])[CH3:40])=[CH:34][C:35]=2[O:36][CH2:37][CH3:38])=[O:8])[CH2:3]1.[C:43](O)(=[O:47])[C:44]([NH2:46])=[O:45]>>[C:39]([C:33]1[N:32]=[CH:31][C:30]([C:10]2[N:9]([C:7]([N:4]3[CH2:5][CH2:6][CH:2]([NH:1][C:43](=[O:47])[C:44]([NH2:46])=[O:45])[CH2:3]3)=[O:8])[C@@:13]([C:15]3[CH:16]=[CH:17][C:18]([Cl:21])=[CH:19][CH:20]=3)([CH3:14])[C@@:12]([C:23]3[CH:24]=[CH:25][C:26]([Cl:29])=[CH:27][CH:28]=3)([CH3:22])[N:11]=2)=[C:35]([O:36][CH2:37][CH3:38])[CH:34]=1)([CH3:41])([CH3:40])[CH3:42]

Participants

Reactant 2

HCID 974Oxamic Acid

HCID 57670089HCID 57670089, compound

Product 1

HCID 57670128HCID 57670128, compound

Procedure

In a manner analogous to the method described in examples 99, (3-amino-pyrrolidin-1-yl )-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-methanone was coupled with oxalamic acid (Aldrich) to give the title product. HR-MS (ES, m/z) calculated for C35H41Cl2N6O4 [(M+H)+] 679.2561, observed 679.2561.

Sources & evidence

ORD record: ord-fdd1291e073e4e1597794930d27e28fe
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08513239B2

Reaction notes

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