2,3,4,5-tetrahydro-1H-1,5-benzodiazepine → HCID 57670143, 화합물

HRID 1894450노트

반응식

HRID 1894450 반응식
[C:1]([C:5]1[N:10]=[CH:9][C:8]([C:11]2[N:12]([C:32](Cl)=[O:33])[C@@:13]([C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=3)([CH3:24])[C@@:14]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)([CH3:16])[N:15]=2)=[C:7]([O:35][CH2:36][CH3:37])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[NH:38]1[CH2:44][CH2:43][CH2:42][NH:41][C:40]2[CH:45]=[CH:46][CH:47]=[CH:48][C:39]1=2>>[C:1]([C:5]1[N:10]=[CH:9][C:8]([C:11]2[N:12]([C:32]([N:38]3[CH2:44][CH2:43][CH2:42][NH:41][C:40]4[CH:45]=[CH:46][CH:47]=[CH:48][C:39]3=4)=[O:33])[C@@:13]([C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=3)([CH3:24])[C@@:14]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)([CH3:16])[N:15]=2)=[C:7]([O:35][CH2:36][CH3:37])[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

3

반응물 2

HCID 5771922,3,4,5-tetrahydro-1H-1,5-benzodiazepineHCID 57669958(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride

생성물 1

HCID 57670143HCID 57670143, 화합물

실험 절차

In a manner analogous to the method described in examples 8, (4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride (example 51) was coupled with 2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine (Aldrich) to give the title compound. HR-MS (ES, m/z) calculated for C38H42Cl2N5O2 [(M+H)+] 670.271, observed 670.2712.

출처 및 근거

ORD 기록
ord-15481e17cf854793845cb8088a4150c2
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08513239B2

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