3-Amino-1,2-propanediol → HCID 57670104, compound

HRID 1894565Notes

Reaction equation

HRID 1894565 reaction equation
[C:1]([C:5]1[N:10]=[CH:9][C:8]([C:11]2[N:12]([C:32]([N:34]3[CH2:39][CH2:38][CH:37]([NH:40][CH2:41][C:42](O)=[O:43])[CH2:36][CH2:35]3)=[O:33])[C@@:13]([C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=3)([CH3:24])[C@@:14]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)([CH3:16])[N:15]=2)=[C:7]([O:45][CH2:46][CH3:47])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH:48][CH:49]([CH2:52][OH:53])[CH2:50][NH2:51]>>[C:1]([C:5]1[N:10]=[CH:9][C:8]([C:11]2[N:12]([C:32]([N:34]3[CH2:39][CH2:38][CH:37]([NH:40][CH2:41][C:42]([NH:51][CH2:50][CH:49]([OH:48])[CH2:52][OH:53])=[O:43])[CH2:36][CH2:35]3)=[O:33])[C@@:13]([C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=3)([CH3:24])[C@@:14]([C:17]3[CH:18]=[CH:19][C:20]([Cl:23])=[CH:21][CH:22]=3)([CH3:16])[N:15]=2)=[C:7]([O:45][CH2:46][CH3:47])[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 735613-Amino-1,2-propanediolHCID 57669922HCID 57669922, compound

Product 1

HCID 57670104HCID 57670104, compound

Procedure

In a manner analogous to the method described in example 163, {1-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidin-4-ylamino}-acetic acid (example 229) was reacted with N-(2,3-dihydroxy-propyl)-amine (Aldrich) to give the title compound as a mixture of diasteromers. HR-MS (ES, m/z) calculated for C39H51Cl2N6O5 [(M+H)+] 753.3293, observed 753.3293.

Sources & evidence

ORD record
ord-a278cf5858f64e82a77b316bdd5abee4
Source dataset
uspto-grants-2013_08
Patent number
US08513239B2

Reaction notes

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