Ethanol → HCID 86624480, compound

Participants

Reaction Steps

To a mixture of methyl 3-(4-(pyridin-2-yloxymethyl)-phenyl)-oxiran-2-carboxylate (19.9 g) described in Manufacturing Example 1-3-1 and ethanol (300 mL) were added sodium methoxide (14.2 mL, 28% methanol solution), water (1.3 mL), and tetrahydrofuran (100 mL) in that order at 0° C., which was stirred for 1 hour at room temperature. Diethyl ether (200 mL) was added to the reaction mixture, and the precipitated solids were collected by filtration, so as to obtain the title compound (14.3 g).

Provenance & Evidence