Ethanol → HCID 86624480, compound

HRID 1894682Notes

Reaction equation

HRID 1894682 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[O:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]2[O:17][CH:16]2[C:18]([O:20]C)=[O:19])=[CH:11][CH:10]=1.C(O)C.C[O-].[Na+:27].O>C(OCC)C.O1CCCC1>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[O:7][CH2:8][C:9]1[CH:10]=[CH:11][C:12]([CH:15]2[O:17][CH:16]2[C:18]([O-:20])=[O:19])=[CH:13][CH:14]=1.[Na+:27]

Participants

7

Reactant 4

HCID 702EthanolHCID 962WaterHCID 10942334Sodium MethoxideHCID 59841575HCID 59841575, compound

Product 1

HCID 86624480HCID 86624480, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a mixture of methyl 3-(4-(pyridin-2-yloxymethyl)-phenyl)-oxiran-2-carboxylate (19.9 g) described in Manufacturing Example 1-3-1 and ethanol (300 mL) were added sodium methoxide (14.2 mL, 28% methanol solution), water (1.3 mL), and tetrahydrofuran (100 mL) in that order at 0° C., which was stirred for 1 hour at room temperature. Diethyl ether (200 mL) was added to the reaction mixture, and the precipitated solids were collected by filtration, so as to obtain the title compound (14.3 g).

Workup

  1. filtrationthe precipitated solids were collected by filtration

Sources & evidence

ORD record
ord-dd3c2a09c3174469b0629fb43c222362
Source dataset
uspto-grants-2013_08
Patent number
US08513287B2

Reaction notes

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