反应详情

To a dichloromethane 70 mL suspension of 4-(2,4,6-trifluorobenzoyl)-1H-pyrrole-2-carboxylic acid (Intermediate 1) (3 g, 11.2 mmol) was added diazomethane solution in diethyl ether upon cooling in an ice-water bath. After stirring for 3 hr, the reaction mixture was concentrated and chromatographed on silica gel eluting with a gradient solvent mixture of AcOEt and hexanes to give the title compound (2.74 g).

1. temperatureupon cooling in an ice-water bath
2. concentrationthe reaction mixture was concentrated
3. customchromatographed on silica gel eluting with a gradient solvent mixture of AcOEt and hexanes