Dichloromethane → methyl 4-(2,4,6-trifluorobenzoyl)-1H-pyrrole-2-carboxylate

Participants

Reaction Steps

To a dichloromethane 70 mL suspension of 4-(2,4,6-trifluorobenzoyl)-1H-pyrrole-2-carboxylic acid (Intermediate 1) (3 g, 11.2 mmol) was added diazomethane solution in diethyl ether upon cooling in an ice-water bath. After stirring for 3 hr, the reaction mixture was concentrated and chromatographed on silica gel eluting with a gradient solvent mixture of AcOEt and hexanes to give the title compound (2.74 g).

Provenance & Evidence