反应详情

To a 37.5 mL THF solution of tert-butyl[2-(2-acetylhydrazino)-2-oxoethyl]carbamate (496 mg, 2.15 mmol) was added Lawesson's reagent (900 mg, 2.23 mmol). The resulting reaction mixture was heated to reflux for 3 hr. The reaction was concentrated and chromatographed on silica gel eluting with a gradient solvent mixture of AcOEt & dichloromethane to give the title compound as white crystalline solid (391 mg).

1. customThe resulting reaction mixture
2. temperaturewas heated
3. temperatureto reflux for 3 hr
4. concentrationThe reaction was concentrated
5. customchromatographed on silica gel eluting with a gradient solvent mixture of AcOEt & dichloromethane