Hydrochloric Acid → (5-Methyl-1,3,4-thiadiazol-2-yl)methanamine hydrochloride

Participants

Reaction Steps

Upon cooling in an ice-water bath, to a 6 mL 4M hydrogen chloride solution in 1,4-dioxane was added the tert-butyl[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]carbamate (391 mg, 1.71 mmol). After the stirring for 1 hr, the reaction mixture was concentrated to give the title compound as white solid (351 mg).

Provenance & Evidence