Hydrochloric Acid → (5-Methyl-1,3,4-thiadiazol-2-yl)methanamine hydrochloride

HRID 1894715Notes

Reaction equation

HRID 1894715 reaction equation
[ClH:1].C(OC(=O)[NH:8][CH2:9][C:10]1[S:11][C:12]([CH3:15])=[N:13][N:14]=1)(C)(C)C>O1CCOCC1>[ClH:1].[CH3:15][C:12]1[S:11][C:10]([CH2:9][NH2:8])=[N:14][N:13]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59892191Tert-butyl ((5-methyl-1,3,4-thiadiazol-2-yl)methyl)carbamate

Product 1

HCID 11615231(5-Methyl-1,3,4-thiadiazol-2-yl)methanamine hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Upon cooling in an ice-water bath, to a 6 mL 4M hydrogen chloride solution in 1,4-dioxane was added the tert-butyl[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]carbamate (391 mg, 1.71 mmol). After the stirring for 1 hr, the reaction mixture was concentrated to give the title compound as white solid (351 mg).

Workup

  1. concentrationthe reaction mixture was concentrated

Sources & evidence

ORD record
ord-9ad0f9ed7e8442ad81ceaefa7594134a
Source dataset
uspto-grants-2013_08
Patent number
US08513289B2

Reaction notes

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