Octanoyl chloride → HCID 12554948, compound

HRID 1894793Notes

Reaction equation

HRID 1894793 reaction equation
Cl.CN.[CH2:4]([N:6](CC)CC)C.[C:11](Cl)(=[O:19])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]>ClCCl>[CH3:4][NH:6][C:11](=[O:19])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

Participants

5

Reactant 3

HCID 8124Octanoyl chlorideHCID 8471TriethylamineHCID 6364545Methylamine hydrochloride

Product 1

HCID 12554948HCID 12554948, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

25 g (0.37 mol) of methylamine hydrochloride are dissolved in 125 mL of dichloromethane, and 115 mL of triethylamine are then added. At 0° C., 70 mL (0.41 mol) of octanoyl chloride are added slowly. The reaction mixture is stirred for 3 hours at room temperature. The mixture is filtered and 100 ml of water are then added to the filtrate. The organic phase is separated out by settling, dried over sodium sulfate and evaporated. 61 g of N-methyloctanamide are obtained in quantitative yield.

Workup

  1. filtrationThe mixture is filtered
  2. addition100 ml of water are then added to the filtrate
  3. customThe organic phase is separated out
  4. dry with materialdried over sodium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-0fe13d91958741ad8eb15d9555513e5d
Source dataset
uspto-grants-2013_08
Patent number
US08513297B2

Reaction notes

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