反应详情

温度

100 °C

340 mg (1.34 mmol) of 2-chloro-N-(2,6-diisopropylphenyl)acetamide (obtained in Example 3/c) are added to 270 mg (1.32 mmol) of (1-amino-methylcyclohexyl)phenylamine (obtained in Example 2/b) in 10 ml of dimethylformamide. The reaction medium is stirred at 100° C. under microwave irradiation for 30 min. It is then poured into water and extracted with ethyl acetate. The organic phases are collected and washed with water and then dried over sodium sulfate. The solvents are evaporated. The residue is chromatographed on silica gel (heptane/ethyl acetate 80/20, v/v). 396 mg of N-(2,6-diisopropylphenyl)-2-[(1-phenylaminocyclohexylmethyl)-amino]acetamide are obtained in the form of a white solid. M.p. 104-6° C., yield=71%.

1. extractionextracted with ethyl acetate
2. customThe organic phases are collected
3. washwashed with water
4. dry with materialdried over sodium sulfate
5. customThe solvents are evaporated
6. customThe residue is chromatographed on silica gel (heptane/ethyl acetate 80/20