反应详情

580 mg (1.94 mmol) of 2-bromo-N-(2,6-diisopropylphenyl)acetamide are added to 400 mg (1.96 mmol) of (1-aminomethylcyclohexyl)phenylamine (obtained in Example 2/b) in 20 ml of dimethylformamide. The reaction medium is stirred at room temperature for 48 h. It is then poured into water and extracted with ethyl acetate. The organic phases are collected and washed with water. They are dried over sodium sulfate. The solvents are evaporated. The residue is chromatographed on silica gel (heptane/ethyl acetate 60/40, v/v). 309 mg of N-(2,6-diisopropylphenyl)-2-[(1-phenylamino-cyclohexylmethyl)amino]acetamide are obtained in the form of a yellowish oil. Yield=37%.

1. extractionextracted with ethyl acetate
2. customThe organic phases are collected
3. washwashed with water
4. dry with materialThey are dried over sodium sulfate
5. customThe solvents are evaporated
6. customThe residue is chromatographed on silica gel (heptane/ethyl acetate 60/40