HCID 67646998, compound → 3-(1-(BOC-amino)-1-cyclopropyl-methyl)pyrrolidine

HRID 1895Notes

Reaction equation

HRID 1895 reaction equation
[C:1]([NH:8][CH:9]([CH:13]1[CH2:17][CH2:16][N:15](CC2C=CC=CC=2)[CH2:14]1)[CH:10]1[CH2:12][CH2:11]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]>CO.[Pd]>[C:1]([NH:8][CH:9]([CH:13]1[CH2:17][CH2:16][NH:15][CH2:14]1)[CH:10]1[CH2:11][CH2:12]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

Participants

4

Reactant 1

HCID 67646998HCID 67646998, compound

Product 1

HCID 196914723-(1-(BOC-amino)-1-cyclopropyl-methyl)pyrrolidineYield 35.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A sample (548 mg) of the compound from step 470d was dissolved in methanol, 140 mg of 10% Pd/C was added, and the mixture was hydrogenated at 4 atm H2 for 42 hours at room temperature. The solution was filtered, and the solvent was removed to give 140 mg of the title compound.

Workup

  1. filtrationThe solution was filtered
  2. customthe solvent was removed

Sources & evidence

ORD record
ord-599ef965de604788a8f4493886ac4c46
Source dataset
uspto-grants-1998_03
Patent number
US05726182

Reaction notes

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