Tetrahydrofuran → 2-(3-Pyridinylamino)-4-thiazolecarboxylic acid

HRID 1895391Notes

Reaction equation

HRID 1895391 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[C:8]([NH:11][C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[S:9][CH:10]=1)=[O:5])C.O1CCCC1.[OH-].[Na+]>CO>[N:14]1[CH:15]=[CH:16][CH:17]=[C:12]([NH:11][C:8]2[S:9][CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=2)[CH:13]=1

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 52903990HCID 52903990, compound

Product 1

HCID 529035842-(3-Pyridinylamino)-4-thiazolecarboxylic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-(Pyridin-3-ylamino)-thiazole-4-carboxylic acid (165 mg) was prepared according to General Procedure C using 2-(pyridin-3-ylamino)-thiazole-4-carboxylic acid ethyl ester in methanol:tetrahydrofuran:2N NaOH (1:1:1, 1.5 mL). The solvents were evaporated and the compound was dried. The crude product was used without further purification.

Workup

  1. customThe solvents were evaporated
  2. customthe compound was dried
  3. customThe crude product was used without further purification

Sources & evidence

ORD record
ord-95270e6983294e26ab93f029557e5b78
Source dataset
uspto-grants-2013_08
Patent number
US08513430B2

Reaction notes

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