Bromopyruvic Acid → 2-[(2-Phenylethyl)amino]-4-thiazolecarboxylic acid

HRID 1895393Notes

Reaction equation

HRID 1895393 reaction equation
[CH2:1]([NH:9][C:10]([NH2:12])=[S:11])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Br[CH2:14][C:15](=O)[C:16]([OH:18])=[O:17]>CO>[CH2:1]([NH:9][C:10]1[S:11][CH:14]=[C:15]([C:16]([OH:18])=[O:17])[N:12]=1)[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 70684Bromopyruvic AcidHCID 735845(2-Phenylethyl)thiourea

Product 1

HCID 805678792-[(2-Phenylethyl)amino]-4-thiazolecarboxylic acidYield 94.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-Phenethylamino-thiazole-4-carboxylic acid (235 mg) was prepared according to General Procedure B using phenethyl-thiourea (180 mg) and 3-bromo-2-oxo-propionic acid (167 mg) in methanol (2 mL). The crude product was used in a subsequent step without further purification.

Workup

  1. customThe crude product was used in a subsequent step without further purification

Sources & evidence

ORD record
ord-9800e22d0b2b49ea99dc471d6019f74b
Source dataset
uspto-grants-2013_08
Patent number
US08513430B2

Reaction notes

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