Bromopyruvic Acid → 2-(2-Pyridin-2-yl-ethylamino)-thiazole-4-carboxylic acid

HRID 1895394Notes

Reaction equation

HRID 1895394 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][NH:9][C:10]([NH2:12])=[S:11].Br[CH2:14][C:15](=O)[C:16]([OH:18])=[O:17]>CO>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][NH:9][C:10]1[S:11][CH:14]=[C:15]([C:16]([OH:18])=[O:17])[N:12]=1

Participants

4

Reactant 2

HCID 70684Bromopyruvic AcidHCID 23143296[2-(Pyridin-2-yl)ethyl]thiourea

Product 1

HCID 805679142-(2-Pyridin-2-yl-ethylamino)-thiazole-4-carboxylic acidYield 90.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-(2-Pyridin-2-yl-ethylamino)-thiazole-4-carboxylic acid (375 mg) was prepared according to General Procedure B using (2-pyridin-2-yl-ethyl)-thiourea (300 mg) and 3-bromo-2-oxo-propionic acid (295 mg) in methanol (3 mL). The crude product was used in a subsequent step without further purification.

Workup

  1. customThe crude product was used in a subsequent step without further purification

Sources & evidence

ORD record
ord-8abf9cd9a2474e27b46b08e393132b17
Source dataset
uspto-grants-2013_08
Patent number
US08513430B2

Reaction notes

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