Bromopyruvic Acid → 2-(4-Trifluoromethyl-phenylamino)-thiazole-4-carboxylic acid

HRID 1895395Notes

Reaction equation

HRID 1895395 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([NH2:12])=[S:11])=[CH:5][CH:4]=1.Br[CH2:16][C:17](=O)[C:18]([OH:20])=[O:19]>CO>[F:14][C:2]([F:1])([F:13])[C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10]2[S:11][CH:16]=[C:17]([C:18]([OH:20])=[O:19])[N:12]=2)=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 70684Bromopyruvic AcidHCID 2777727N-[4-(Trifluoromethyl)phenyl]thiourea

Product 1

HCID 27607532-(4-Trifluoromethyl-phenylamino)-thiazole-4-carboxylic acidYield 95.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-(4-Trifluoromethyl-phenylamino)-thiazole-4-carboxylic acid (275 mg) was prepared according to General Procedure B using (4-trifluoromethyl-phenyl)-thiourea (220 mg) and 3-bromo-2-oxo-propionic acid (200 mg) in methanol (2 mL). The crude product was used in a subsequent step without further purification.

Workup

  1. customThe crude product was used in a subsequent step without further purification

Sources & evidence

ORD record
ord-6e8cfc9575f94570af7ffea24786a90a
Source dataset
uspto-grants-2013_08
Patent number
US08513430B2

Reaction notes

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