HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromopyruvic Acid → 2-(4-Trifluoromethyl-phenylamino)-thiazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromopyruvic Acid | HCID 70684 | — |
| Reactant | N-[4-(Trifluoromethyl)phenyl]thiourea | HCID 2777727 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(4-Trifluoromethyl-phenylamino)-thiazole-4-carboxylic acid | HCID 2760753 | 95.5% |
Reaction Steps
2-(4-Trifluoromethyl-phenylamino)-thiazole-4-carboxylic acid (275 mg) was prepared according to General Procedure B using (4-trifluoromethyl-phenyl)-thiourea (220 mg) and 3-bromo-2-oxo-propionic acid (200 mg) in methanol (2 mL). The crude product was used in a subsequent step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08513430B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-6e8cfc9575f94570af7ffea24786a90a |
| Source note | uspto-grants-2013_08 |