Bromopyruvic Acid → 2-[(4-Methoxyphenyl)amino]-4-thiazolecarboxylic acid

HRID 1895396Notes

Reaction equation

HRID 1895396 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([NH2:12])=[S:11])=[CH:5][CH:4]=1.Br[CH2:14][C:15](=O)[C:16]([OH:18])=[O:17]>CO>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10]2[S:11][CH:14]=[C:15]([C:16]([OH:18])=[O:17])[N:12]=2)=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 70684Bromopyruvic AcidHCID 6675494-Thioureidoanisole

Product 1

HCID 27596312-[(4-Methoxyphenyl)amino]-4-thiazolecarboxylic acidYield 94.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-(4-Methoxy-phenylamino)-thiazole-4-carboxylic acid (237 mg) was prepared according to General Procedure B using (4-methoxy-phenyl)-thiourea (182 mg) and 3-bromo-2-oxo-propionic acid (200 mg) in methanol (2 mL). The crude product was used in a subsequent step without further purification.

Workup

  1. customThe crude product was used in a subsequent step without further purification

Sources & evidence

ORD record
ord-f9afc583ba2b4e658d6c2505336d4a96
Source dataset
uspto-grants-2013_08
Patent number
US08513430B2

Reaction notes

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