反应详情

温度

40 °C

A mixture of tert-butyl 2-(4-carbamoyl-1H-benzo[d]imidazol-2-yl)-3,4-dihydroquinoline-1(2H)-carboxylate (17 mg, 0.043 mmol) and HCl in methanol (1.25 M, 1 mL) was stirred at 40° C. overnight. Methanol was removed under reduced pressure, aq. sodium bicarbonate solution was added and extracted with DCM. The DCM layer was washed with brine, dried over anhydrous sodium sulfate and evaporated to afford 2-(1,2,3,4-Tetrahydroquinolin-2-yl)-1H-benzo[d]imidazole-4-carboxamide. MS (ES+): m/z 315.13 [M+Na]+

1. customMethanol was removed under reduced pressure, aq. sodium bicarbonate solution
2. additionwas added
3. extractionextracted with DCM
4. washThe DCM layer was washed with brine
5. dry with materialdried over anhydrous sodium sulfate
6. customevaporated