Formamide → 3,4-Dihydro-6-hydroxy-4-oxoquinazoline

HRID 1895873Notes

Reaction equation

HRID 1895873 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][C:3]=1[C:4](O)=[O:5].[CH:12]([NH2:14])=O>>[OH:11][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[N:1]=[CH:12][NH:14][C:4]2=[O:5]

Participants

3

Reactant 2

HCID 713FormamideHCID 1645925-Hydroxyanthranilic acid

Product 1

HCID 1354895773,4-Dihydro-6-hydroxy-4-oxoquinazoline

Conditions

Temperature
190 °C

Procedure

To a solution of 2-amino-5-hydroxybenzoic acid 0201 (30.6 g, 0.2 mol) in formamide was stirred and heated to 190° C. for 0.5 h. The mixture was allowed to cool to room temperature.

Workup

  1. temperatureto cool to room temperature

Sources & evidence

ORD record
ord-9fcb802f9d6f4c4eb02be2bdf3a4464c
Source dataset
uspto-grants-2013_08
Patent number
US08518910B2

Reaction notes

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