Sodium Hydroxide → HCID 86652727, compound

HRID 1895912Notes

Reaction equation

HRID 1895912 reaction equation
[OH-].[Na+].C([O:5][C:6](=[O:31])[C:7]([NH:9][O:10][CH:11]1[CH2:16][CH2:15][N:14]([S:17]([C:20]2[CH:25]=[CH:24][C:23]([O:26][C:27]([F:30])([F:29])[F:28])=[CH:22][CH:21]=2)(=[O:19])=[O:18])[CH2:13][CH2:12]1)=[O:8])C>O1CCCC1CO>[F:30][C:27]([F:28])([F:29])[O:26][C:23]1[CH:24]=[CH:25][C:20]([S:17]([N:14]2[CH2:15][CH2:16][CH:11]([O:10][NH:9][C:7](=[O:8])[C:6]([OH:31])=[O:5])[CH2:12][CH2:13]2)(=[O:19])=[O:18])=[CH:21][CH:22]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86652726HCID 86652726, compound

Product 1

HCID 86652727HCID 86652727, compound

Reagents, catalysts & solvents 1

HCID 7360Tetrahydrofurfuryl alcoholSolvent

Procedure

Aqueous 1 N NaOH solution (5 ml) was added to a solution of N-[1-(4-trifluoromethoxybenzenesulfonyl)piperidin-4-yloxy]oxalamic acid ethyl ester in tetrahydrofuran-methanol (1:1, 10 ml) and stirred at room temperature for 1 hour. The reaction was quenched with aqueous 1 N HCl solution (6 ml). The resulting precipitation was collected and washed with H2O to give N-[1-(4-trifluoromethoxybenzenesulfonyl)piperidin-4-yloxy]oxalamic acid (422 mg).

Workup

  1. customThe reaction was quenched with aqueous 1 N HCl solution (6 ml)
  2. customThe resulting precipitation
  3. customwas collected
  4. washwashed with H2O

Sources & evidence

ORD record
ord-31ec5e0722d44594b435dff3cbe674d6
Source dataset
uspto-grants-2013_08
Patent number
US08518934B2

Reaction notes

Loading…