反应详情

Trifluoroacetic acid (3.42 g, 30.0 mmol) was added to a solution of (S)-tert-butyl 3-(1,3-dioxoisoindolin-2-yloxy)pyrrolidin-1-carboxylate (3.32 g, 10.0 mmol) CH2Cl2 (25 ml) at 0° C. The reaction mixture was stirred at room temperature for 17 hours and concentrated in vacuo. The residue was triturated with diethyl ether (100 ml) to give (S)-2-(pyrrolidin-3-yloxy)isoindoline-1,3-dione)trifluoroacetic acid salt (2.77 g, 80%) as a white solid.

1. concentrationconcentrated in vacuo
2. customThe residue was triturated with diethyl ether (100 ml)