Hydrochloric Acid → HCID 86652736, compound

HRID 1895931Notes

Reaction equation

HRID 1895931 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:25])[NH:10][O:11][CH:12]2[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)=[CH:4][CH:3]=1.[ClH:26]>O1CCOCC1>[ClH:26].[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:10][O:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[O:25])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86652735HCID 86652735, compound

Product 1

HCID 86652736HCID 86652736, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of tert-butyl 4-(3-(4-fluorophenyl)ureidooxy)piperidine-1-carboxylate (1.5 g, 4.2 mmol) and 1 N HCl solution in dioxane (25 ml) was stirred at room temperature for 3 hours and concentrated in vauo. The residual solid was triturated with diethyl ether (100 ml) to give 1-(4-fluorophenyl)-3-(piperidin-4-yloxy)urea hydrochloride (1.1 g, 90%) as a white solid.

Workup

  1. concentrationconcentrated in vauo
  2. customThe residual solid was triturated with diethyl ether (100 ml)

Sources & evidence

ORD record
ord-3cbf214750414f999182fa02b46d5de3
Source dataset
uspto-grants-2013_08
Patent number
US08518934B2

Reaction notes

Loading…