反应详情

Sulfuryl dichloride (1.22 ml, 15.0 mmol) was added at room temperature to a solution of N-methylpiperazine (0.555 ml, 5.00 mmol) in acetonitrile (10 ml) and the whole was stirred under reflux for 6 hours. The reaction mixture was concentrated in vacuo and the resulting solid was collected and washed with diethyl ether to give 4-methylpiperazine-1-sulfonyl chloride hydrochloride.

1. temperatureunder reflux for 6 hours
2. concentrationThe reaction mixture was concentrated in vacuo
3. customthe resulting solid was collected
4. washwashed with diethyl ether