Sulfuryl chloride → 4-Methylpiperazine-1-sulfonyl chloride--hydrogen chloride (1/1)

HRID 1895933Notes

Reaction equation

HRID 1895933 reaction equation
[S:1]([Cl:5])([Cl:4])(=[O:3])=[O:2].[CH3:6][N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1>C(#N)C>[ClH:4].[CH3:6][N:7]1[CH2:12][CH2:11][N:10]([S:1]([Cl:5])(=[O:3])=[O:2])[CH2:9][CH2:8]1

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 531671-Methylpiperazine

Product 1

HCID 187987054-Methylpiperazine-1-sulfonyl chloride--hydrogen chloride (1/1)

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Sulfuryl dichloride (1.22 ml, 15.0 mmol) was added at room temperature to a solution of N-methylpiperazine (0.555 ml, 5.00 mmol) in acetonitrile (10 ml) and the whole was stirred under reflux for 6 hours. The reaction mixture was concentrated in vacuo and the resulting solid was collected and washed with diethyl ether to give 4-methylpiperazine-1-sulfonyl chloride hydrochloride.

Workup

  1. temperatureunder reflux for 6 hours
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. customthe resulting solid was collected
  4. washwashed with diethyl ether

Sources & evidence

ORD record
ord-21751239acb14ae0a0c79b32c2769ed4
Source dataset
uspto-grants-2013_08
Patent number
US08518934B2

Reaction notes

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