反应详情

A solution of Compound 1b (0.57 g, 1.81 mmol), tetra-n-butylammonium fluoride hydrate (0.57 g, 2.03 mmol) in 38 mL of THF was stirred at r.t. for 2 h. The reaction mixture was poured into water and extracted with EtOAc. The combined organic layers were washed with brine, dried on Na2SO4 and evaporated to dryness in vacuo to afford a residue, which was purified by flash chromatography (EtOAc—Petroleum Ether 1:9) giving the title product (0.21 g).

1. extractionextracted with EtOAc
2. washThe combined organic layers were washed with brine
3. customdried on Na2SO4
4. customevaporated to dryness in vacuo
5. customto afford a residue, which
6. customwas purified by flash chromatography (EtOAc—Petroleum Ether 1:9)